Septins at a glance.

Septins from the Phytopathogenic Fungus Ustilago maydis Are Required for Proper Morphogenesis but Dispensable for Virulence

BACKGROUND Septins are a highly conserved family of GTP-binding proteins involved in multiple cellular functions, including cell division and morphogenesis. Studies of septins in fungal cells underpin a clear correlation between septin-based structures and fungal morphology, providing clues to understand the molecular frame behind the varied morphologies found in fungal world. METHODOLOGY/PRI...

Chemicals and Infertility at a Glance

Septins are involved at the early stages of macroautophagy

Autophagy is a conserved cellular degradation pathway where in a double membrane vesicle, called as an autophagosome captures long lived proteins, damaged or superfluous organelles and delivers to lysosome for degradation 8 . We have identified a novel role for septins in autophagy. Septins are GTP binding proteins that localize at the bud-neck and are involved in cytokinesis in budding yeast. ...

Uncovering the Roles of Septins in Cilia

Septins are a family of GTP-binding proteins that associate with cellular membranes and the cytoskeleton. Their ability to polymerize into filamentous structures permits them to serve as diffusion barriers for membrane proteins and as multi-molecular scaffolds that recruit components of signaling pathways. At the cellular level, septins contribute to the regulation of numerous processes, includ...

Functional Redundancy of Septin Homologs in Dendritic Branching

Septins are cytoskeletal GTPases present in nonpolar heteromeric complexes that assemble in a palindromic fashion from two to eight subunits. Mammalian septins function in several fundamental cellular processes at the membrane-cytoskeleton interface including dendritic branching in neurons. Sequence homology divides the 13 mammalian septin genes into four homology groups. Experimental findings ...